Direct carbon-carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters.

نویسندگان

  • Julianne M Yost
  • Rachel J Alfie
  • Emily M Tarsis
  • Insun Chong
  • Don M Coltart
چکیده

α-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr(2)·OEt(2) and i-Pr(2)NEt to produce α-halo-β-hydroxy thioesters.

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Direct carbon-carbon bond formation via reductive soft enolization: a kinetically controlled syn-aldol addition of α-halo thioesters and enolizable aldehydes.

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عنوان ژورنال:
  • Chemical communications

دوره 47 1  شماره 

صفحات  -

تاریخ انتشار 2011